谭洁琼,男,博士,伟德BETVLCTOR1946医学遗传学研究中心副研究员,博士生导师,哈佛医学院波士顿儿童医院博士后。湖南省神经退行性疾病专业委员会副主委,湖南省神经科学学会理事,湖南省遗传学会委员。主持国家自然科学青年基金、面上项目、博士点新教师基金;承担国家重点研发计划子课题,作为课题骨干参与包括973项目、卫生部行业基金、国家自然科学基金重点项目、国际合作项目等在内的各级科研项目10余项;以第一作者或通讯作者在J Cell Biol. , Brain,J Biol Chem,Br J Dermatol等杂志上发表SCI论文10余篇。现研究方向为神经退行性疾病的的分子病理机制。
代表性论文:
1.Zhao, Y. W., Pan, H. X., Zeng, Q., Fang, Z. H., Liu, Z. H., Wang, Y., Jiang, L., He, R., Zhou, X., Zhou, Y. J., Xu, Q., Sun, Q. Y., Li, B., Zhao, G., Yang, Y., Hu, Y. C., Chen, Y. S., Du, J., Lei, L. F., Zhang, H. N., Wang, C. Y., Yan, X. X., Shen, L., Jiang, H., Li, J. C., Tang, B. S.,Tan, J*., and Guo, J. F*. PSAP variants in Parkinson's disease: a large cohort study in Chinese mainland population. Brain 2021,144, e25
2.Wang R#,Tan J#, Chen T, Han H, Tian R, Tan Y, Wu Y, Cui J, Chen F, Li J, Lv L, Guan X1, Shang S, Lu J, Zhang Z. ATP13A2 Facilitates HDAC6 Recruitment to Lysosome to Promote Autophagosome-Lysosome Fusion. J Cell Biol. 2019 Jan 7;218(1):267-284.
3.Zhu T, Tian D, Zhang L, Xu X, Xia K, Hu Z, Xiong Z*,Tan J*. Novel mutations in mevalonate kinase cause disseminated superficial actinic porokeratosis. Br J Dermatol. 2018 Dec 30.
4.Cai C.#, Zhou H., Yuan N., Wu M., Lee S., Ren J., Su H., Lu J., Chen X., Li M.,Tan J.*, Lu J.*, Natural alkaloid harmine promotes degradation of Alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation, Phytomedicine 2019.
5.Qin L.X.#,Tan J.#, Zhang H.N., Rizwana K., Lu J.H., Tang J.G., Jiang B., Shen X.M., Guo J.F., Tang B.S., Tan L.M., Wang C.Y.*, BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage, Oxid Med Cell Longev 2017,2017:5094934.
6.Tan J#., Zhang T., Jiang L., Chi J., Hu D., Pan Q., Wang D., Zhang Z*. Regulation of intracellular manganese homeostasis by Kufor-Rakeb syndrome-associated ATP13A2 protein. The Journal of biological chemistry, 2011, 286:29654-62.