教育经历

1993.9-1997.7 吉林大学生物化学专业 学士

1997.9-2002.7中国科学院上海生物化学与细胞生物学研究所 博士

工作经历

2002.9-2004.3美国纽约爱因斯坦医学院分子药理学系 博士后

2004.4-2005.6浙江养生堂天然药物研究所 部门主管

2005.6-今 伟德BETVLCTOR1946细胞生物学系 副教授、教授

2012.3-2014.8美国密西西比大学医学中心癌症研究所 访问学者

行政职务

伟德BETVLCTOR1946细胞生物学系主任

社会兼职

Cell Journal 编委

学术奖励

1.教学质量优秀奖．2007-2008

2.优秀班导师. 2009-2011

研究方向

肿瘤生物学、天然药物活性组分与药效

研究简介

在分子、细胞、模式动物和临床等多层次上，从事细胞信号转导、肿瘤发生发展机制、肿瘤细胞耐药机制、天然药物药理作用等方面的研究。

（1）以Notch信号转导通路为核心，探索乳腺癌、胰腺癌和前列腺癌等多种肿瘤发生、发展的分子机制，确定关键靶标分子，寻找有效诊断与治疗肿瘤的方法。

（2）天然药物有效成分的分离与提取及其药理作用的研究。

代表性论文

1.Zhang S, Liu J, Xu K, Li Z. Notch signaling via regulation of RB and p-AKT but not PIK3CG contributes to MIA PaCa-2 cell growth and migration to affect pancreatic carcinogenesis. Oncology Letters. 2018 Feb;15(2):2105-2110

2.Chung WC, Zhang S, Challagundla L, Zhou Y, Xu K. Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer. Neoplasia. 2017 Nov;19(11):885-895.

3.Shubing Zhang, Dewen Qiu, Jingjiang Liu, Zhijian Li. Active Components of Fungus Shiraia bambusiscola Can Specifically Induce BGC823 Gastric Cancer Cell Apoptosis. Cell Journal(Yakhteh),2016，Jul-Sep (Summer) , 18(2) : 149-158

4.Zhang S, Chung WC, Xu K. Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer. Oncogene. 2016 May 12;35(19):2485-95

5.Zhang S, Chung WC, Wu G, Egan SE, Miele L, Xu K. Manic Fringe Promotes a Claudin-Low Breast Cancer Phenotype through Notch-Mediated PIK3CG Induction. Cancer Research. 2015 May 15;75(10):1936-43

6.Zhang S, Chung WC, Wu G, Egan SE, Xu K. Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation. Neoplasia. 2014 Feb;16(2):158-67.

7.Zhang S, Chung WC, Miele L, Xu K. Targeting Met and Notch in the Lfng-deficient, Met-amplified triple-negative breast cancer. Cancer Biology & Therapy. 2014 May;15(5):633-42.

8.Zhang S, Loch AJ, Radtke F, Egan SE, Xu K.Jagged1 is the major regulator of Notch-dependent cell fate in proximal airways. Developmental Dynamics 2013 Jun;242(6):678-86.

9.张树冰,周亚玲,李凌,李杰．真菌竹黄双向调节TNF-α诱导的L929细胞凋亡过程.天然产物研究与开发．2012,24(12):1733-1737

10.Rongbao Zhao, Shubing Zhang, Marie Hanscom, Shrikanta Chattopadhyay and I. David Goldman. Loss of Reduced Folate Carrier Function and Folate Depletion Result in Enhanced Pemetrexed Inhibition of Purine Synthesis. Clinical Cancer Research. 2005,11(3): 1294-1301

11.Shubing Zhang, Jian huang, Hui Zhao, Yi Zhang, Chunhui Hou, Xiaodong Cheng, Chu Jiang, Minqian Li, Jun Hu, Ruolan Qian. The in vitro reconstitution of nucleosome and its binding patterns with HMG1/2 and HMG 14/17. Cell Research (2003);13(5):351-359.

12.Zhang Shubing, Qian Ruolan. The interaction between the human beta-globin locus control region and nuclear matrix .Cell Research, (2002); 12(5-6):411-416.

13.Zhang Shubing, Qiye He, Hui Zhao, Changyun Gui, Chu jiang, Ruolan Qian. Function of GATA ranscription factors in hydroxyurea-induced HEL cells. Cell Research. 2001;11(4):301-310

14.Zhang Shubing, Zhao Hui, Jiang Chu, et al.Interactions between GATAtranscription factors and the DNaseI hypersensitive sites in the humanbeta-globin gene LCR. Chinese Science Bulletin. 2000,45(21): 1969-1973